Ca 2+ Mg 2+-ATPase activity of synaptosome fraction and synaptosomal membranes from different areas of rat brain. Lachowicz, L., Janiszewska, G., Wojtkowiak, R., Wojtkowiak Z, 1983. Ectonucleotidases and synaptic plasticity: Implications in physiological and pathological conditions. Ectonucleotidases: Molecular structures, catalytic properties, and functional roles in the nervous system. Ectonucleotidases: Some recent developments and a note on nomenclature. Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. Effect of long-term caffeine treatment on A 1 and A 2 adenosine receptor binding and on mRNA levels in rat brain. Johansson, B., Ahlberg, S., van der Ploeg, I., Brené, S., Lindefors, N., Persson, H., and Fredholm, B. Adenosine A 1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. 8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo. L., Gallo-Rodriguez, C., Maillard, M., and Daly, J. Adenosine/dopamine interaction: Implications for the treatment of Parkinson's disease. Fine tuning neuromodulation by adenosine. Nomenclature and classification of adenosine receptors. International Union of Pharmacology, XXV. The role and regulation of adenosine in the central nervous system. Caffeine as a model drug of dependence: Recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome and caffeine negative reinforcement. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. B., Battig, K., Holmen, J., Nehlig, A., and Zvartau, E. This activation of ATP and ADP hydrolysis after acute treatment suggests a compensatory effect to increase adenosine levels and counteract the antagonist action of caffeine.įredholm, B. However, acute administration of caffeine (30 mg/kg, ip) produced an enhancement of ATP (50%) and ADP (32%) hydrolysis in synaptosomes of hippocampus and striatum, respectively. Caffeine chronically administered in the drinking water at 0.3 g/L or 1 g/L for 14 days failed to affect nucleotide hydrolysis. Caffeine and theophylline tested in vitro were unable to modify nucleotide hydrolysis. This study verified the effect of caffeine on NTP-Dase 1 (ATP diphosphohydrolase) and 5′-nucleotidase of synaptosomes from hippocampus and striatum of rats. The availability of extracellular adenosine depends on its release by transporters or by the extracellular ATP catabolism performed by the ecto-nucleotidase pathway. The psychostimulant caffeine promotes behavioral effects such as hyperlocomotion, anxiety, and disruption of sleep by blockade of adenosine receptors.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |